心理药物多药导致可逆性痴呆症:一个案例报告
Durjoy Lahiri1, Bruna Seixas-Lima, Carlos Roncero
1Temerty Faculty of Medicine, Memory Disorders Clinic, Baycrest Academy for Research and Education and the Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada.
概括
心理药物多药可以模仿神经退行性疾病,导致显著的认知能力下降. 停止处方这些药物可以导致完全的认知恢复和改善日常功能.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 临床药房 临床药房
背景情况:
- 心理药物多药是一种诊断挑战,往往因不完整的药物历史而恶化.
- 多种精神药物的认知效应经常被低估.
- 将药物诱导的认知障碍与神经退行症区分开来至关重要.
研究的目的:
- 突出心理药物多药物可能导致可逆性认知衰退的潜力.
- 强调在记忆诊所进行彻底药物检查的重要性.
- 在临床上适当时倡导抑郁症的处方.
主要方法:
- 一个57岁的老人患有渐进性认知衰退的病例报告.
- 综合评估包括神经心理测试,脑成像和脑脊液生物标志物.
- 药物审查和随后的精神药物和阿片类药物的减记.
主要成果:
- 最初的评估表明神经退行性疾病,但阿尔茨海默病的生物标志物是负的.
- 患者因药物过量使用而经历了阿片类药物过量服用.
- 在停止所有精神活性药物后,认知障碍的完全逆转和恢复独立性发生.
结论:
- 心理药物多药可以表现为各种认知症状,临床医生必须认识到这些症状.
- 彻底的药物调和对于认知衰退患者的准确诊断至关重要.
- 处方不必要的精神药物可以导致显著的认知改善.
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