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坚持地中海饮食与慢性胰腺炎风险降低有关:一项纵向队列研究
Chunhua Zhou1, Jiawei Geng2, Hanyi Huang3
1Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China. zdwrjxh66@sjtu.edu.cn.
Food & function
|October 21, 2024
概括
坚持地中海饮食 (MedDiet) 可以显著降低患慢性胰腺炎 (CP) 的风险. 这项大规模的英国研究发现,更高的MedDiet坚持与CP的发病率降低相关.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 饮食模式对慢性胰腺炎 (CP) 风险的影响仍未得到充分研究.
- 虽然地中海饮食 (MedDiet) 已知具有健康益处,但其与CP发病率的具体关联尚不清楚.
- 这项研究解决了理解饮食在CP病因学中的作用的差距.
研究的目的:
- 调查遵守地中海饮食 (MedDiet) 与慢性胰腺炎 (CP) 发生率之间的关联.
- 探索炎症和代谢状态在这种关系中的潜在调解作用.
主要方法:
- 利用了来自190,790名最初没有CP的参与者的英国生物库数据.
- 使用地中海饮食坚持选器 (MEDAS) 连续得分评估MedDiet坚持.
- 采用多变量考克斯回归和调解分析,通过多个健康注册证实了CP诊断.
主要成果:
- 在平均10.8年的随访期间,发现了214例CP病例.
- 最高的MedDiet坚持与显著降低CP风险有关 (HR=0.57,95%CI:0.40-0.82).
- 代谢状态部分调解了这种关联 (4.74%),而C-反应蛋白没有显示出显著的调解效应.
结论:
- 增加对地中海饮食的坚持与患慢性胰腺炎的风险降低有关.
- 饮食模式,特别是MedDiet,代表了预防CP的潜在可修改因素.
- 代谢因素可能在饮食如何影响CP风险方面发挥作用.
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