局部抗氧化剂可可多透透皮肤的可可多
Zoe Diana Draelos1, Matthew M Draelos1, Sue Feng2
1Dermatology Consulting Services, PLLC, High Point, North Carolina, USA.
Journal of cosmetic dermatology
|October 21, 2024
概括
局部使用的可可粉可以将抗氧化剂甲素和甲素输送到皮肤角层. 这项研究表明它们在应用后1-2小时内沉积,支持潜在的皮肤学益处.
科学领域:
- 皮肤病学和化品
- 自然产品化学 自然产品化学
- 皮肤屏障功能 皮肤屏障功能
背景情况:
- 来自Theobroma可可的可可粉含有丰富的抗氧化物多,如甲素和甲素.
- 虽然口服摄入的多具有抗氧化功效,但它们的局部皮肤透,特别是进入角层,仍然没有得到证实.
- 这项研究解决了有关可可多在皮肤上的局部疗效的知识差距.
研究的目的:
- 为了证明catechin和epicatechin在角层中的沉积.
- 在可可粉局部应用1个小时和2个小时后,量化聚醇水平.
- 研究可可粉作为皮肤局部抗氧化剂来源的潜力.
主要方法:
- 五名健康的女性受试者将6%的可可粉溶液涂在前臂上.
- 在施用后1个小时和2个小时,使用带剥离采集了角质层样本.
- 使用液体染色学质谱法 (LC-MS) 分析了甲基素和基素水平.
主要成果:
- 应用后1个小时和2个小时,在角层中检测到catechin和epicatechin.
- 与甲素相比,观察到甲素的度更高,与可可粉成分一致.
- 虽然水平从1小时增加到2小时,但这种差异在统计学上并不显著.
结论:
- 局部应用6%的水性可可粉成功地将甲素和甲素输送到角层.
- 这些发现支持可可衍生化合物的潜在使用,作为皮肤健康的局部抗氧化剂.
- 进一步的研究可以探索优化的配方,以提高皮肤透率和疗效.
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