在患有先天性心脏病的新生儿中,个性化皮质转化
Daniel Cromb1, Siân Wilson1,2,3,4, Alexandra F Bonthrone1
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Brain communications
|October 21, 2024
概括
患有先天性心脏病的婴儿表现出大脑缩的减少,主要是由于大脑的大小较小,皮层折叠没有改变. 大脑的氧气输送对这些婴儿的大脑生长的影响比折叠更大.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 儿童心脏病学 儿童心脏病学
背景情况:
- 先天性心脏病 (CHD) 与大脑发育障碍和神经发育问题有关.
- 患有心血管疾病的婴儿早期大脑发育需要进一步调查结构变化.
研究的目的:
- 为了比较患有心脏病的婴儿和典型发育的婴儿的手术前皮层转化指数 (CGI).
- 调查CGI,大脑氧气供应和患有心脏病的婴儿的神经发育结果之间的关系.
主要方法:
- 采用了规范型建模方法,对142名患有心脏病的婴儿和320名对照进行了研究.
- 使用考虑年龄,性别和大脑体积的模型生成化指数Z-scores.
- 与22个月的大脑氧气供应和神经发育评估相关的Z-分数.
主要成果:
- 全球和区域大脑转化在患有心脏病的新生儿中显著减少,但当考虑 supratentorial大脑体积时,这种差异消失了.
- 脑部氧气输送与心脏病婴儿的全脑CGI正相关,但只有当脑体积不被考虑时.
- 在22个月后,CGI和运动/认知结果或自闭症特征之间没有发现显著的关联.
结论:
- 降低心血管疾病婴儿的皮层折叠主要是由大脑尺寸的减少驱动的,而不是折叠本身的发育轨迹的改变.
- 在患有心脏病的婴儿中,大脑的氧气输送可能会影响大脑体积增长,而不是皮质折叠.
- 慢性心脏病缺氧与皮层折叠的减少有关,与 supratentorial 脑体积减少成比例.
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