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在诊断虹膜黑色素瘤时,眼内压力和杯与圆盘比不对称

Alan W Kong¹, Adrian Au¹, Weilin Song¹

¹Department of Ophthalmology, Stein Eye Institute, University of California Los Angeles, Los Angeles, CA, USA.

Clinical ophthalmology (Auckland, N.Z.)

|October 21, 2024

概括

虹膜黑色素瘤与受影响的眼睛中的眼内压力 (IOP) 和杯与光盘比率 (CDR) 比受影响的眼睛更高. 这种IOP和CDR的不对称性可能有助于区分虹膜黑色素瘤和虹膜神经瘤.

科学领域:

眼科医生眼科眼科
眼科瘤学眼科瘤学
玻璃眼研究研究玻璃眼研究

背景情况:

从临床上讲,区分虹膜黑色素瘤和虹膜神经是具有挑战性的.
有限的临床特征,除了记录的生长,帮助诊断.
眼内压力 (IOP) 和杯与盘的比率 (CDR) 是眼睛健康的关键指标.

研究的目的:

在患有虹膜黑色素瘤和虹膜神经瘤的患者中,在受影响和不受影响的眼睛之间比较呈现的IOP和CDR.
确定潜在的生物标志物,以区分虹膜黑色素瘤和虹膜瘤.
为了研究虹膜瘤和玻璃眼瘤指标之间的关系.

主要方法:

一个机构的回顾性案例系列 (2013年1月 - 2022年10月).
包括39名虹膜黑色素瘤患者和40名与年龄相匹配的虹膜神经患者.
分析了受影响眼睛和不受影响眼睛之间的IOP,CDR和青光眼的诊断差异.

主要成果:

虹膜黑色素瘤眼睛的平均IOP (18.8±6.1 mmHg) 和CDR (0.36±0.27) 与虹膜神经眼睛 (IOP: 14.6±3.5 mmHg,CDR: 0.24±0.14) 相比显著更高.
虹膜黑色素瘤患者在受影响和不受影响的眼睛之间表现出更大的IOP不对称性 (P=0.03).
在虹膜黑色素瘤患者 (P=0.05) 中观察到受影响眼睛CDR较高的趋势.

结论:

与不受影响的眼睛相比,虹膜黑色素瘤与受影响的眼睛中的高IOP和CDR有关.
眼睛之间较大的IOP不对称可能表明虹膜黑色素瘤.
IOP和CDR不对称性是虹膜黑色素瘤的潜在诊断线索.

关键词:

杯与盘的比例是杯与盘的比例.眼内压力眼内压力虹膜黑色素瘤是什么意思虹膜神经管子虹膜神经管子二次性玻璃眼眼的情况.

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