定期使用非类固醇抗炎药物增加了一般人群的压力骨折风险:一项回顾性病例对照研究
Alexandra Ciuciu1, Christopher Mulholland1, Michael A Bozzi1
1Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia 19107, PA, USA.
Advances in orthopedics
|October 21, 2024
概括
定期使用非类固醇抗炎药物 (NSAIDs),如布洛芬和纳普罗森,与一般人群中压力骨折的风险更高有关. 患者应考虑避免服用这些药物,以减少骨折发生率.
科学领域:
- 整形外科 整形外科 整形外科
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 非类固醇抗炎药物 (NSAIDs) 与压力骨折风险增加有关,主要在运动员中进行研究.
- 有限的数据存在于NSAID使用和压力骨折在一般人群中,尽管显著的公共卫生影响.
- 临床前研究表明,NSAIDs可能会损害骨的内在骨折抵抗力.
研究的目的:
- 在一般人群中调查经常使用NSAID和压力骨折之间的关联.
- 为了比较患有压力骨折的个体和对照组之间的NSAID使用模式.
主要方法:
- 一项病例对照研究调查了56名压力骨折患者和51名对照患者 (不复杂的脚扭伤).
- 在受伤前三个月的NSAID使用 (当前和定期) 经过验证的问卷被评估.
- 用费舍尔的精确测试来分析不同组之间NSAID使用的差异.
主要成果:
- 与对照人群相比,患有压力骨折的个体显示,与对照人群相比,目前和定期使用布洛芬,纳普罗森和塞莱科西布的使用量有统计学上的显著增加.
- 在使用阿司匹林,乙氨基或含有乙氨基的处方药时没有发现显著差异.
- 在定期使用特定的NSAID和压力骨折发生率之间观察到强烈的相关性.
结论:
- 定期使用布洛芬,纳普罗森或切莱科西布与一般人群中压力骨折的发病率较高有关.
- 这些发现支持了之前的临床观察,并突出了骨损伤的潜在风险因素.
- 被确定为压力骨折高风险的患者应考虑避免定期使用这些常见的NSAID.
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