使用电子医疗记录数据对体重减轻维护的四年随访:PROPEL试验
Peter T Katzmarzyk1, Emily F Mire1, Ronald Horswell1
1Pennington Biomedical Research Center Baton Rouge Louisiana USA.
Obesity science & practice
|October 21, 2024
概括
强化生活方式干预 (ILI) 促进短期减肥,但体重恢复发生在2年后. 然而,在ILI患者中观察到显著的体重减轻维护,在干预停止时达到≥5%或≥10%的体重减轻.
科学领域:
- 肥胖研究的研究.
- 临床营养学 临床营养学
- 行为医学是一种行为医学.
背景情况:
- 短期减肥可以通过各种干预措施实现.
- 在结构化计划后,在自由生活条件下长期维持减肥仍然是一个重大挑战.
研究的目的:
- 为了比较2年的强化生活方式干预 (ILI) 与常规护理 (UC) 的体重轨迹.
- 为了评估ILI和UC组的干预后长达4年的体重变化.
主要方法:
- 使用来自参与诊所的电子病历 (EMR) 来提取数据.
- 定义基线为在试验开始日期之前最接近EMR数据点.
- 分析了111名LI患者和196名UC患者的体重轨迹.
主要成果:
- 在第100天和第700天之间,ILI组的体重减轻明显高于UC组.
- 在第700天之后,在两组之间没有观察到体重减轻的显著差异.
- 在24个月内保持≥5%和≥10%体重减轻的ILI组患者在整个干预和随访期间显著增加体重减轻 (p < 0.001).
结论:
- 虽然ILI患者经历了24个月后重量恢复到基线,减少了群体差异,但那些达到实质性的初始体重减轻的患者保持了更长时间.
- 在积极干预阶段结束时实现显著 (≥5%或≥10%) 减肥的个体中,持续减肥的可能性更高.
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