与Candida相关的急性纤维性和组织性肺炎:一个病例报告
Zhengtu Li1, Beini Xu1, Jie Liu1
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Respiratory medicine case reports
|October 21, 2024
概括
急性纤维化和组织性肺炎 (AFOP) 是一种罕见的肺部疾病. 这一案例突出了与Candida的潜在关联,强调了包括肺活检和病理学在内的全面诊断的必要性.
科学领域:
- 肺部病理学 肺部病理学
- 病理学 病理学 病理学
- 传染性疾病 传染性疾病
背景情况:
- 急性纤维化和组织性肺炎 (AFOP) 是一种罕见的肺炎,其特征在于肺气膜和间隔膜中的纤维素沉积.
- AFOP呈现出非特异性的临床特征,使诊断复杂化.
- 本报告详细介绍了一例可能与坎迪达菌感染相关的AFOP病例.
研究的目的:
- 描述一个独特的AFOP病例,可能与Candida有关.
- 加强对AFOP的理解和诊断方法.
- 为了说明复杂的AFOP病例的诊断挑战和成功治疗.
主要方法:
- 最初的错误诊断是社区获得的肺炎 (CAP),经过无效的实证治疗.
- 灵活的支气管检查与元基因组学 下一代测序 (mNGS) 支气管膜洗液 (BALF) 阳性 菌.
- 超声波引导的皮肤肺活检用于病理性确认AFOP,组织的mNGS也表明Candida.
主要成果:
- 最初接受CAP治疗的患者没有改善.
- mNGS在BALF和肺组织中发现了Candida albicans.
- 病理学检查证实了AFOP,患者对皮质类固醇治疗反应良好.
结论:
- 诊断AFOP需要综合临床,辅助和病理发现的综合方法,因为非特异性测试是常见的.
- 排除其他疾病并将AFOP分类为特异性或二次性对于适当的治疗选择至关重要.
- 这一案例强调了在AFOP诊断和管理中考虑菌共感染 (如Candida) 的重要性.
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