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与FeNO结合的脉冲振荡计与学龄前儿童中喘控制的关系
Jiying Xiao1, Lingyue Liu1, Kamran Ali2
1Department of Pulmonology, Hangzhou Children's Hospital, Hangzhou, Zhejiang, 310015, People's Republic of China.
Journal of asthma and allergy
|October 21, 2024
概括
分数呼出的氧化 (FeNO) 和冲动振荡计 (IOS) 在患有喘的学前儿童中显示出显著的差异. FeNO是控制喘的强有力的预测指标,IOS在组合时适度提高了其预测值.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 过敏和免疫学 过敏和免疫学
背景情况:
- 在学龄前儿童中控制喘仍然是一个临床挑战,需要改进诊断和预测工具.
- 脉冲振荡计 (IOS) 和分数呼出的氧化 (FeNO) 是对呼吸道功能和炎症的非侵入性测量.
- 了解它们在评估幼儿喘控制中的作用对于有效管理至关重要.
研究的目的:
- 分析控制,不受控制的喘和健康的学龄前儿童之间的IOS和FeNO指标的差异.
- 评估IOS和FeNO的预测价值,单独和组合,用于识别这个年龄段的不受控制的喘.
主要方法:
- 研究对象包括171名患有喘的学龄前儿童和30名健康对照儿童.
- 在3个月的随访后评估了喘控制,将儿童分为受控 (n=85) 和不受控制 (n=86) 组.
- 在基线测量IOS和FeNO,并使用接收器操作特征曲线 (AUROC) 分析来确定辨别能力.
主要成果:
- 在控制和不受控制的喘组之间观察到IOS参数 (R5,X5,R5-R20,Fres) 的显著差异.
- 部分呼出的氧化 (FeNO) 单独表现出高分辨能力 (AUROC=0.88) 对于不受控制的喘.
- 将IOS指标与FeNO相结合进一步增强了预测能力,R5-R20+FeNO实现了最高的AUROC0.92.
结论:
- IOS和FeNO都显示出与学龄前儿童喘控制相关的显著差异.
- FeNO成为控制喘的主要预测因素,提供了实质性的歧视价值.
- 将IOS指标与FeNO集成,可以适度地提高对失控喘的预测能力.
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