怀孕期间的卡路里限制会影响小鼠的母体和后代便微生物组
Stephanie P Gilley1, Meghan L Ruebel2,3, Sree V Chintapalli3,4
1Department of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO, United States.
Frontiers in endocrinology
|October 21, 2024
概括
孕产妇的卡路里限制会导致胎儿生长受限,并改变母体和后代的肠道微生物群. 这些微生物变化可能会影响后代的生长和成人健康.
科学领域:
- 微生物学 微生物学
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 孕产妇营养不良是胎儿生长限制 (FGR) 的主要原因之一.
- FGR与婴儿发病率和死亡率以及肥胖和2型糖尿病等成人发病情况有关.
- 母婴和后代微生物组对FGR结果的影响仍然不清楚.
研究的目的:
- 研究母体卡路里限制 (CR) 对母体和后代肠道微生物群的影响.
- 探索微生物组成和后代生长参数之间的关联.
主要方法:
- 通过30%的母体卡路里限制 (CR) 在小鼠中诱导胎儿生长限制 (FGR).
- 在多个时间点记录下后代的体重.
- 来自母体和后代的便样本使用16S rRNA基因测序进行了分析.
- 使用MaAsLin2和基于距离的冗余分析来评估微生物的分类丰度.
主要成果:
- 在CR水中,肠道微生物的多样性发生了变化,特定细菌的数量较低 (例如Turicibacter,Flexispira).
- 与对照组相比,FGR后代在3周和4周年龄时表现出明显的微生物特征,其中包括Akkermansia和Sutterella等关键类型的变化.
- 孕产妇的Helicobacter丰富度与后代体重有正相关,而后代的Akkermansia丰富度与成人体重有负相关.
结论:
- 孕妇的卡路里限制会在孕妇及其后代中诱导肠道微生物失调.
- 这些发现凸显了微生物组在调解母亲营养对后代发育影响方面的潜在作用.
- 需要进一步的研究来阐明这些微生物改变在FGR结果中的功能意义.
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