严重肺炎儿童凝血功能指标的临床价值
Jun Song1, Ning Li1, Ruihua Li1
1Department of Pediatrics, Taihe County People's Hospital, Fuyang, Anhui, 236000, People's Republic of China.
International journal of general medicine
|October 21, 2024
概括
在严重的肺炎中观察到像D-二聚合物和纤维素降解产物这样的高凝血指标,有助于临床评估和预后评估.
科学领域:
- 儿科 儿科 儿科
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 严重的肺炎带来复杂的临床挑战,通常涉及全身并发症.
- 凝血功能障碍越来越被认为是严重儿科疾病的重要因素.
研究的目的:
- 调查严重肺炎儿童凝血功能指标的变化.
- 确定这些指标在诊断和预测预后方面的临床意义.
主要方法:
- 在患有重症肺炎的儿童中,测量了前列血时间 (PT),激活的部分血栓形成时间 (APTT),纤维素 (FIB),D-二次体 (D-D) 和纤维素降解产物 (FDP).
- 采用皮尔森相关性,ROC曲线分析和后勤回归来评估指标相关性和诊断/预测能力.
主要成果:
- 与普通肺炎相比,严重的肺炎病例中的凝血指标 (PT,APTT,FIB,FDP,D-D) 显着更高.
- FDP和D-D水平与儿科临床严重程度评分 (PCIS) 有负相关性.
- 升高的PT,APTT,FIB,FDP和DDD与预后不佳有关,FDP和APTT被确定为关键预后因素.
结论:
- 在严重的肺炎中,凝血功能指标升高.
- 监测这些标志物有助于临床判断疾病严重程度和儿童的预后评估.
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