患有异形性炎症性肌肉病的患者的长期缺食症严重程度:单中心回顾性研究
Shin-Ichiro Ohmura1, Keishiro Sato2, Ritsu Nishimura3
1Rheumatology, Seirei Hamamatsu General Hospital, Hamamatsu, JPN.
Cureus
|October 21, 2024
概括
患有消化不良的异常性炎症性肌肉病 (IIM) 患者表现出改善的吞功能,口服摄入率为72.2%. 然而,生存结果较差,特别是当恶性瘤存在时.
科学领域:
- 神经学 神经学
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
背景情况:
- 异形性炎症性肌肉病 (IIM) 包含影响肌肉的罕见自身免疫性疾病.
- 缺食症是影响IIM患者生活质量和预后的重大并发症.
- 了解IIM中缺食症的长期结果对于患者管理至关重要.
研究的目的:
- 评估日本IIM患者的长期消化不良严重程度和生存率.
- 为了确定一个年内完全口服的消化不良发作的速度.
- 确定影响IIM患者存活时间的预后因素.
主要方法:
- 在2000年4月至2022年3月期间,对108名日本IIM患者进行了回顾性研究.
- 使用食物摄入水平尺度 (FILS) 评估消化不良的严重程度.
- 通过Cox回归分析分析了完整的口服摄入率和整体死亡率.
主要成果:
- 16.7%的IIM患者患有食障碍. 在IIM患者中,有16.7%的人患有食障碍.
- 中位数的消化不良严重程度从FILS 7.0提高到10.0.
- 一年内全口服摄入率为72.2%;缺血症患者的整体死亡率为44.4%.
- 恶性瘤相关的肌肉炎是一个不良的预后因素;生存率更差,同时发生的恶性瘤.
结论:
- 在IIM患者中,缺食症的严重程度通常会改善.
- 虽然吞功能恢复了,但整体生存率仍然令人担忧,特别是在患有恶性瘤的人群中.
- 早期识别和治疗食障碍和相关疾病对于IIM患者的治疗结果至关重要.
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