眼睛表面和视网膜的微血管变化 结合性组织疾病相关的间歇性肺病
Li-Ming Chen1, Min Kang2, Jun-Yi Wang3
1Department of Rheumatology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
International journal of ophthalmology
|October 21, 2024
概括
与连接组织疾病相关的间歇性肺病 (CTD-ILD) 患者与健康个体相比,视网膜微血管密度显著降低. 这种眼部微血管变化可能是CTD-ILD的早期指标,有助于疾病管理.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
背景情况:
- 连接组织疾病相关的间歇性肺病 (CTD-ILD) 可以影响多个器官系统.
- 眼部微血管变化可能是系统性疾病的早期指标.
研究的目的:
- 为了比较CTD-ILD患者和健康对照者 (HCs) 之间的斑点视网膜血管密度,使用光学连贯断层扫描血管学 (OCTA).
- 研究CTD-ILD患者眼睛中微血管密度的变化.
主要方法:
- 一项追溯病例控制研究,涉及16名CTD-ILD患者和16名匹配的HC.
- OCTA用于分析表面和深层视网膜层,计算微血管,大血管和总微血管密度.
- 视网膜血管密度使用中央环状,半球和ETDRS细分方法进行评估.
主要成果:
- 与HC患者相比,CTD-ILD患者在表面和深层视网膜中表现出明显较低的斑点视网膜微血管密度 (MIR和TMI).
- 通过使用不同的细分方法 (半球,ETDRS,中央环) 在各种视网膜区域观察到血管密度的减少.
- 在CTD-ILD患者中,结膜血管密度和视网膜微血管密度之间发现了负相关性.
结论:
- 与HC相比,CTD-ILD患者的视网膜微血管密度显著降低.
- 观察到的眼部微血管变化,特别是与结膜血管密度的反相关性,表明它有可能成为CTD-ILD的早期诊断标志物.
- 监测眼睛的微循环可以提高结合组织疾病的早期检测和管理.
相关概念视频
01:22Microbiome of the Eye
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...