半合成植物化学品在癌症治疗中:药物化学的视角
Meghna Arora1, Ankit Kumar Singh1,2, Adarsh Kumar1
1Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab Ghudda Bathinda 151401 India meghnaarora33@gmail.com ankitsinghpbh12195@gmail.com adarshkumar5198@gmail.com harshwardhansingh371995@gmail.com pradeepyadav27@gmail.com pradeep.kumar@cup.edu.in.
天然产品及其衍生物在癌症治疗中至关重要,半合成和合成化合物越来越重要. 本综述强调了关键的植物成分及其在开发新型抗癌剂中的作用.
科学领域:
- 药理学和瘤学 药理学和瘤学
- 自然产品化学 自然产品化学
背景情况:
- 自然产品及其衍生品占FDA批准的新分子实体 (NME) 的很大一部分.
- 从历史上看,未经修改的天然产品是普遍存在的,但半合成和合成衍生品自20世纪40年代以来获得了突出地位.
- 由于不受控制的细胞增殖和转移,癌症仍然是导致死亡的主要原因.
研究的目的:
- 审查FDA批准的和经过临床试验的植物成分,其化学修饰具有抗癌潜力.
- 讨论癌症治疗的半合成植物成分的最新进展.
- 突出自然产品衍生物的重要性,因为它们有助于开发新型抗癌药物.
主要方法:
- 对FDA批准的新分子实体 (NME) 进行全面审查.
- 对天然产品衍生药物的历史趋势的分析.
- 详细讨论特定的分离植物成分及其半合成衍生物.
主要成果:
- 自然产品和衍生品占所有NME的三分之一以上.
- 未经修改的天然产品的比例已经下降,而衍生品现在占批准的NME的28%.
- 几个关键的植物成分 (例如, podophyllotoxin,Taxol,vinca类化合物) 和它们的衍生物在癌症治疗中至关重要.
结论:
- 化学修饰的植物成分是开发新型抗癌药物的重要线索.
- 自然物质的半合成衍生物继续成为癌症药物发现和开发的主要焦点.
- 这些化合物在当前的癌症治疗策略中起着至关重要的作用.
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