立方体使用和冠状动脉化在CKD的进展:来自KNOW-CKD研究的发现
Jihyun Yang1, Kyu-Beck Lee1, Hyang Kim1
1Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Kidney international reports
|October 21, 2024
概括
立方体使用与韩国成年人前透析慢性病 (CKD) 的冠状动脉化 (CAC) 进展更快有关. 这一发现表明,在这个脆弱的患者群体中,他类药物可能会矛盾地加速CAC.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 类药物被广泛用于降低心血管疾病 (CVD) 风险.
- 之前的研究表明,他类药物的使用与冠状动脉化 (CAC) 进展有关,这些患者的功能保存或透析.
- 在透析前慢性病 (CKD) 中,他类药物的使用和CAC进展之间的关系在很大程度上是未知的.
研究的目的:
- 调查他类药物使用与冠状动脉化 (CAC) 在韩国成年人前透析慢性病 (CKD) 的进展之间的关联.
- 在这个特定的患者队列中,描述他类药物使用和CAC进展之间的关系.
主要方法:
- 对1177名韩国队列研究的参与者进行的慢性病患者 (KNOW-CKD) 结局分析.
- 冠状动脉分数 (CACS) 通过心脏计算机断层扫描在基线和4年后进行评估.
- 使用Sevrukov方法定义的CAC进展;用他类药物的人被定义为使用他类药物≥50%的随访期.
主要成果:
- 4年后,52.0%的参与者显示CAC进展.
- 与非使用者 (41.7%) 相比,使用他类药物的人 (58.3%) 的CAC进展明显更频繁 (P < 0.001).
- 在他类药物使用者与非使用者之间,CAC进展的多变量调整的几率比为1.78 (1.26-2.50).
结论:
- 达丁类药物的使用与韩国患者患有预透析CKD的加快CAC进展有显著且独立的关联.
- 需要进一步的研究,以了解这种人群中与他类药物相关的CAC进展的预后影响.
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