曼尼托尔对接受冠状动脉旁路手术的患者的术后功能的影响:双盲随机对照试验
Masumeh Hemmati Maslakpak1, Eisa Bilejani2, Sohrab Negargar2
1Maternal and Childhood Obesity Research Center, Nursing and Midwifery School, Urmia University of Medical, Urmia, Iran.
Journal of cardiovascular and thoracic research
|October 21, 2024
概括
将曼尼托尔添加到心肺绕道主要溶液中并不能改善功能或减少冠状动脉绕道手术患者的并发症. 这项研究表明,曼尼托尔不是心脏手术后急性损伤的预防策略.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 手术创新 在外科创新.
背景情况:
- 曼尼托尔是一种透性利尿剂,经常用于心肺绕道 (CPB) 启动.
- 它对心脏手术患者功能潜在的影响需要进行调查.
研究的目的:
- 为了评估添加曼尼托尔到CPB主要溶液对接受冠状动脉旁路手术的患者功能的影响.
主要方法:
- 一个随机的双盲临床试验,涉及90名接受冠状动脉旁路手术的患者.
- 干预组 (n=45) 接受了林格的乳酸盐与200毫升的20%曼尼托尔,而对照组 (n=45) 仅接受了林格的乳酸盐.
- 功能是主要终点,次要评估包括CPB时间,通风持续时间,死亡率和住院时间.
主要成果:
- 关于人口特征,风险因素,CPB/大动脉十字时间,通风持续时间,30天死亡率或ICU/住院时间,在曼尼托尔和对照组之间没有发现显著差异.
- 血清肌和血尿酸 (BUN) 水平在两组之间没有统计学上显著的差异 (分别P=0.53和P=0.13).
- 这两组的利尿率也相似 (P=0.10).
结论:
- 将曼尼托尔添加到CPB原溶液中,并没有明显改善功能或影响关键的临床结果,如通风持续时间,住院时间或死亡率.
- 这些发现表明,曼尼托尔不是心脏手术后急性损伤的有效预防策略.
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