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之前使用阿司匹林对ST升高心肌梗塞患者的左心室功能的影响,这些患者接受了初级皮肤穿冠状动脉干预:心声学评估

Yosef Yosefzadeh¹, Mahdokht Rezaei², Abbas Allami³

¹Department of Cardiology, Bouali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.

Journal of cardiovascular and thoracic research

|October 21, 2024

概括

之前使用阿司匹林并没有显著影响ST升高心肌梗塞 (STEMI) 患者的左心室功能,这些患者正在接受一次性皮肤穿冠状动脉干预 (PPCI). 即使经过对混因素进行调整后,心声学参数仍然保持一致.

科学领域:

心脏病学心脏病学
心血管成像 - 心血管成像
药理学药理学是指药理学的学科.

背景情况:

关于前期阿司匹林使用和ST升高心肌梗塞 (STEMI) 患者在初级皮肤穿冠状动脉干预 (PPCI) 后的心脏功能存在相互矛盾的证据.
左心室 (LV) 功能是STEMI患者结果的关键决定因素.

研究的目的:

研究在接受PPCI的STEMI患者之前使用阿司匹林对LV心声学参数的影响.
为了澄清心脏病发作前的阿司匹林治疗和心脏功能在重血管化后的关系.

主要方法:

分析了接受PPCI的260名STEMI患者的队列.
患者根据先前的阿司匹林使用情况进行了分层.
关键回声心脏学参数包括LV喷射率 (LVEF),左心房 (LA) 尺寸和透气功能指数在入院72小时内被评估.

主要成果:

阿司匹林使用者年龄较大,BMI和功能较低,高血压和其他心血管药物的患病率更高.
在阿司匹林使用者和非使用者之间没有观察到LVEF,最大LA大小,E/A比率或E/e'比率的显著差异.
在阿司匹林使用者中,早期的透析速度 (e') 略低 (P=0.054),但在调整混因子后,这没有达到统计学意义.

结论:

在接受PPCI的STEMI患者中,先前使用阿司匹林并没有显著影响LV心声学参数.
即使考虑到潜在的混变量,这些发现仍然很强大,这表明对心脏功能没有临床显著的影响.

关键词:

亚司匹林是一种阿司匹林.心声回声扫描 (Echocardiography) 是一种心声回声扫描.心脏的心室是心脏的室内.心肌梗塞的心脏病发作通过皮肤进行冠状动脉干预.

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