相关实验视频

Updated: Jun 10, 2025

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

ppHiC:在ProteinPaint网络门户网站上对Hi-C结果进行交互式探索

Akanksha Rajput¹, Colleen Reilly¹, Airen Zaldivar Peraza¹

¹Department of Computational Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States.

Computational and structural biotechnology journal

|October 21, 2024

概括

ProteinPaint Hi-C (ppHiC) 是一个用于从Hi-C数据中可视化3D基因组结构的Web工具. 它简化了复杂的基因组分析,使染色质构成的探索更容易,例如神经母细胞瘤癌症.

科学领域:

基因组学就是基因组学.
生物信息学是一种生物信息学.
分子生物学分子生物学

背景情况:

三维 (3D) 基因组结构对于基因调节至关重要.
Hi-C数据提供了对基因组组织的洞察力,但需要大量的计算才能进行分析.
限制可访问性阻碍了Hi-C数据分析的广泛使用.

研究的目的:

介绍ProteinPaint Hi-C (ppHiC),这是一个用户友好的基于Web的工具,用于Hi-C数据可视化和探索.
为了使没有广泛的计算专业知识的研究人员能够分析复杂的Hi-C数据集.
为了证明ppHiC在理解与癌症相关的基因组改变方面的实用性.

主要方法:

开发一个基于网络的平台,用于 Hi-C 数据可视化.
实现一个可自定义的界面来调整可视化参数.
集成的交互功能为多个规模的基因组视图.

主要成果:

ppHiC提供可访问的,基于Web的大型Hi-C数据集的分析.
该工具支持多个Hi-C数据版本,并提供高度可定制的界面.
证明了神经母细胞瘤中改变色素构成的可视化.

结论:

ppHiC使Hi-C数据分析民主化,使3D基因组结构探索更容易获得.
该工具促进了合作研究和对基因组重组的理解.
使用ppHiC可视化染色体构造可以推进癌症基因组学研究.

关键词:

联系矩阵是一个接触矩阵.基因组的重新安排.这就是Hi-C.蛋白质涂料是一种蛋白质涂料.视觉化的可视化网络服务器的Web服务器.

更多相关视频

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

相关概念视频

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...