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彻底改变快速分解片:利用多孔粉和升华技术的双重方法
Sameer J Nadaf1, Pranav L Savekar2, Durgacharan A Bhagwat3
1Bharati Vidyapeeth College of Pharmacy, Palus 416310, Maharashtra, India.
Heliyon
|October 21, 2024
概括
豆整洁粉 (NS) 通过升华转化为多孔粉 (PS) 增强了快速分解的片 (FDTs). 与NS-FDT相比,PS-FDT显示了改善的分解和药物释放,提供了可行的替代辅助剂.
科学领域:
- 制药科学:药物的配方和药物输送
- 材料科学:多孔材料工程 材料科学:多孔材料工程
- 生物化学:粉修饰 粉修饰
背景情况:
- 快速分解片 (FDTs) 需要有效的分解剂来快速释放药物.
- 传统的超级分解剂,如粉糖 (SSG) 和十字糖 (CS) 有限制.
- 探索新型辅助剂,如改性粉,对于先进的药片配方至关重要.
研究的目的:
- 使用升华技术从纯粉 (NS) 制备多孔粉 (PS).
- 为了评估PS作为基 (DL) 装载的FDT中的分解剂.
- 将PS-FDTs的性能与使用NS和商业超级分解剂 (SSG,CS) 制定的性能进行比较.
主要方法:
- 清洁粉 (NS) 被转化为多孔粉 (PS),使用花作为升华剂.
- 福利埃变换红外光谱法 (FTIR),差分扫描热量计 (DSC) 和粉末X射线衍射 (PXRD) 用于表征.
- 用迪克洛菲纳克 (DL) 装载的FDT是通过直接压缩制备的,随后是分解,溶解和稳定性测试.
主要成果:
- 显微镜分析证实了PS中由于升华而形成的孔隙.
- 与NS (76-104秒) 相比,PS显著减少了FDT分解时间 (50-82秒).
- 在PS-FDT中,药物释放概况与SSG和CS相比相当或更高,在60分钟内释放高达97.65%.
结论:
- 通过升华制备的多孔粉 (PS) 是快速分解片 (FDT) 的有效辅助剂.
- 聚氨酸增强了迪克洛芬纳克的分解和溶解速度.
- 升华技术提供了一种有前途的方法,用于开发新的基于粉的分解剂,以改善口服药物输送.
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