FeNO的变化与喘控制和肺功能相关
Yanmin Gao1, Zhenyu Li2, Nengshun Wu1
1Department of Pediatrics, the Eighth People's Hospital of Wuxi, Wuxi, China.
Heliyon
|October 21, 2024
概括
布德索尼德/福莫特醇吸入粉雾 (B/FIPM) 有效地减少了部分呼出的氧化 (FeNO),并改善了患有喘的儿童的肺功能. 治疗后FeNO水平的变化预测了患者的预后,并与肺功能结果相关.
科学领域:
- 儿科肺病学 儿科肺病学
- 过敏和免疫学 过敏和免疫学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 喘是儿童常见的慢性呼吸道疾病.
- 分数呼出的氧化 (FeNO) 是气道炎症的生物标志物.
- 评估FeNO变化可以提供对治疗疗效和疾病预后的见解.
研究的目的:
- 为了研究FeNO在儿童喘患者治疗后的变化.
- 确定FeNO变化与喘预后之间的关联.
- 探索FeNO变化与肺功能恢复之间的相关性.
主要方法:
- 招募了144名患有喘的儿童,并接受了布德塞尼德/福莫特醇吸入粉雾 (B/FIPM) 的治疗.
- 在基线和治疗后测量FeNO水平.
- 评估结果基于1年后的喘控制 (控制良好与部分控制) 和肺功能.
主要成果:
- B/FIPM疗法显著降低了FeNO度和乙氨基酸细胞数量,改善了肺功能 (P < 0.01).
- 控制良好的喘在1周后显示FeNO减少,而部分控制的喘在2周后显示持续的FeNO减少 (P <0.01).
- FeNO (ΔFeNO >0) 的积极变化与初始FeNO≤35ppb (P = 0.042) 的患者中更高比例的良好控制结果有关.
结论:
- B/FIPM有效降低FeNO和乙氨基基,并改善儿科喘中的肺功能.
- 治疗后的FeNO变化作为喘预后的预测标记.
- 在患有喘的儿童中,FeNO动态与治疗后的肺功能相关.
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