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评估目前随机对照心脏骤停试验的范围:一个范围审查

Jake Toy^1,2,3,4, Lauren Friend⁵, Kelsey Wilhelm^2,3,4

¹Los Angeles County EMS Agency Santa Fe Springs California USA.

Journal of the American College of Emergency Physicians open

|October 21, 2024

概括

心脏骤停随机对照试验 (RCT) 从2015年至2022年没有增加. 在医院内和儿科心脏骤停研究中存在研究缺口,尽管疾病负担很大.

科学领域:

心脏病学心脏病学
临床研究临床研究
公共卫生公共卫生

背景情况:

心脏骤停是一个重大的全球健康挑战.
显著缺乏可靠的随机对照试验 (RCT),以指导临床管理策略.
评估现有RCT的风景对于识别研究缺口至关重要.

研究的目的:

评估2015年至2022年期间发表的心脏骤停RCT的范围和趋势.
确定心脏骤停管理领域的潜在研究缺口.

主要方法:

在2023年10月,在MEDLINE,Embase和Web of Science进行了全面的文献搜索.
包括的研究是2015年至2022年出版的RCT,涉及患有非创伤性心脏骤停的人.
用描述性统计和曼·肯德尔测试来分析出版趋势和试验特征.

主要成果:

包括87个RCT,没有观察到出版物的每年显著增加 (p=1.0).
丹麦和美国在试验贡献方面处于领先地位. 大多数试验的重点是成人,医院外心脏骤停.
干预措施包括过程改进,药物和设备,在医院前和ICU设置以及在逮捕期间和逮捕后期间的类似应用. 在≥28天的生存是常见的初级结局.

结论:

发表的心脏骤停RCT的数量在2015年至2022年期间保持稳定.
发现了大量的研究缺陷,特别是在医院内心脏骤停和儿科患者群体方面.
需要进一步的研究来解决心脏骤停管理中这些研究不足的领域.

关键词:

作为主题的临床试验.心脏停止了,心脏停止了.在医院外发生心脏骤停.随机分配的随机分配是指随机分配.

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