在卡塔尔儿童的败血性关节炎的病因学
Abdullah Khan1, Abdelmoneem Mohammed Elsheikh1, Khalid Alansari1
1Department of Emergency Medicine Sidra Medicine Doha Qatar.
Journal of the American College of Emergency Physicians open
|October 21, 2024
概括
儿童的败血性关节炎通常是由金黄色葡萄球菌引起的. 早期治疗至关重要,建议对格拉姆阳性和格拉姆阴性细菌进行实证抗生素覆盖.
科学领域:
- 儿科整形外科 儿科整形外科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 败血性关节炎是一种关键的骨科疾病,需要及时治疗以防止不良结果.
- 此前关于儿科败血性关节炎病因的研究主要集中在发达国家.
- 在卡塔尔的儿科人口中识别致病原体,包括接种疫苗的儿童,至关重要.
研究的目的:
- 确定卡塔尔以前健康的,完全接种疫苗的儿童感染败血性关节炎的具体原因.
- 分析儿科败血性关节炎病例的临床表现,成像发现和微生物学数据.
- 为该地区儿童败血性关节炎的治疗指南提供信息.
主要方法:
- 在2018年7月至2024年6月期间,对45名被诊断患有败血性关节炎的儿童患者进行了回顾性分析.
- 包括标准包括阳性血液培养,布鲁塞拉标位或突菌培养.
- 用描述性统计数据收集和分析了临床症状,成像和实验室结果的数据.
主要成果:
- 膝盖和部是5岁儿童中位数中最常受到影响的关节.
- 黄金葡萄球菌是占主导地位的病原体 (56%),其次是斯特菌 pyogenes (13%) 和布鲁塞拉 (11%).
- 所有患者都完全康复,没有并发症,尽管金氏菌的报道可能不足.
结论:
- 格拉姆阳性菌,特别是黄金葡萄球菌,仍然是接种疫苗的儿童感染败血性关节炎的主要原因.
- 这项研究确定了格拉姆阴性细菌作为显著的致病原体.
- 对疑似儿科败血性关节炎的经验性抗生素治疗应涵盖Gram阳性和Gram阴性细菌,等待培养结果.
相关概念视频
01:28Gene Regulation in Microbial Communities: Quorum Sensing
3
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
3
01:30Bacterial Signaling
31.5K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
31.5K
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.1K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.1K
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
7
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
7
01:25Urinary Tract Infection II: Pathophysiology
1
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
1