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Updated: Jun 10, 2025

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A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
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阳性库希综合征和上腺抑制呈现为绝经前期
Sarah M Andres1, Jesse M Galina2, Sarah L Berga1
1Department of Obstetrics and Gynecology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA.
JCEM case reports
|October 21, 2024
概括
长时间的关节内皮质类固醇注射会导致二次上腺功能衰竭和阴性库希综合征. 治疗包括补充皮和逐渐停止注射,恢复正常功能.
科学领域:
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
- 内部医学 内部医学
背景情况:
- 二次上腺功能衰竭 (SAI) 是阳性库希综合征的一个严重并发症.
- 关节内皮质类固醇注射 (IAC) 是常见的骨关节炎,但构成SAI的风险.
- 长时间使用IAC可以导致上腺和卵巢抑制.
研究的目的:
- 为了呈现一种因长期使用IAC而产生的阳性库希综合征和SAI的病例.
- 以突出诊断挑战和治疗结果在这种情况下.
- 强调IACs潜在的内分泌干扰作用.
主要方法:
- 一个43岁的女性患有异常子宫出血的病例报告.
- 对绝经前期的评估,揭示了阳性化的库希综合征和SAI.
- 用皮替代剂治疗和用逐渐缩小的IAC停止治疗.
主要成果:
- 患者出现了库辛综合征和SAI的症状.
- 实验室测试证实了由于长时间的IACs而导致的阳性化的库辛综合征和SAI.
- 在治疗后,内源性卵巢和上腺功能在16个月内恢复.
结论:
- 长时间使用IAC可以导致显著的内分泌功能障碍,包括SAI.
- 早期识别和管理对于逆转IAC诱导的上腺抑制至关重要.
- 这一案例凸显了局部皮质类固醇治疗相关的潜在系统性风险.
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