在新辅助免疫疗法后,对甲时多发性结肠癌的观察和等待方法:病例报告
1Department of Gastrointestinal Surgery, Chongqing University Cancer Hospital, Chongqing, ;China.
Frontiers in immunology
|October 21, 2024
概括
新辅助免疫疗法在结肠癌患者中实现了临床完整反应,使得观察和等待方法能够代替手术. 这一案例表明,在精选的结肠癌患者中,有可能进行非手术治疗.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 新辅助免疫疗法在结直肠癌 (CRC) 方面表现有前途.
- 观察和等待 (W&W) 方法是为直肠癌后期治疗建立的.
- 在结肠癌中W&W的应用仍然在很大程度上未被探索.
研究的目的:
- 报告一个用新辅助免疫疗法治疗的结肠癌病例.
- 探索W&W方法在经新辅助免疫治疗后结肠癌中的可行性.
主要方法:
- 一名64岁的男性患有上升性结肠腺癌,接受了新辅助剂pembrolizumab.
- 在四个循环后,获得了临床完整反应 (cCR).
- 实施了W&W战略,省略了手术.
主要成果:
- 患者经历了症状的消失,并实现了cCR.
- 随访证实没有瘤复发或转移.
- 这表明新辅助免疫疗法可以诱导结肠癌中的cCR.
结论:
- 新辅助免疫疗法对特定的CRC亚型 (dMMR/MSI-H) 有效.
- 一个W&W方法可能是一个可行的选择选择选择结肠癌患者后免疫治疗.
- 需要进一步的临床数据来验证W&W在结肠癌中的安全性和可行性.
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