瘤关联中性粒细胞的知识景观:从2000年到2024年进行的文献计量和视觉分析
Chaoyue Xiao1, Xiang Feng1, Wufuer Aini2
1Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China.
Frontiers in immunology
|October 21, 2024
概括
瘤关联中性粒细胞 (TAN) 是癌症中的关键免疫细胞. 这份图书统计分析绘制了TAN研究趋势,强调了异质性和免疫治疗作为未来的重点.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
背景情况:
- 传统上与炎症相关的中性粒细胞现在被认为是瘤微环境的重要组成部分,形成与瘤相关的中性粒细胞 (TAN).
- TANs表现出相当大的异质性和可塑性,在癌症进展中具有多方面的作用.
- 尽管人们越来越感兴趣,但将TAN向免疫疗法转化为临床实践仍然是一个挑战.
研究的目的:
- 对瘤相关中性粒细胞 (TAN) 研究进行全面的文献分析.
- 绘制研究格局的地图,确定关键贡献者,并确定TAN研究的演变趋势.
- 为未来的研究方向和针对TAN的治疗策略提供见解.
主要方法:
- 从2000年到2024年对788篇出版物的图书统计分析,来源于科学网络核心集合.
- 使用包括微软Excel,VOSviewer,CiteSpace和R-bibliometrix在内的工具进行数据分析和可视化.
- 检查出版物数量,机构隶属,国家贡献,期刊影响和引用分析.
主要成果:
- 美国在高质量的出版物和全球合作方面处于领先地位,而中国的出版量最高.
- 免疫学前沿是最富有成效的期刊,癌症研究是最常被引用的.
- 教授Zvi G. Fridlender被认为是TAN研究中引用数量和H指数最高的先驱.
结论:
- 图书统计分析提供了对TAN研究格局和知识结构的全面概述.
- 预计未来的研究将重点关注TAN异质性,中性粒细胞外细胞陷,免疫细胞交叉声和免疫疗法.
- 针对特定的TAN亚群的向为开发有效的TAN向免疫疗法提供了显著的潜力.
相关概念视频
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Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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There are several types of targeted therapies against specific...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...