晚期肺癌炎症指数与慢性病之间的关联:一个横截面研究
Xiaotong Li1, Qian Wang1,2, Feng Wu1
1The Nephrology Department of Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.
Frontiers in nutrition
|October 21, 2024
概括
晚期肺癌炎症指数 (ALI) 与美国成年人的慢性病 (CKD) 风险有关. 较高的ALI水平与患CKD的可能性降低相关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 慢性病 (CKD) 是一个普遍的疾病.
- 营养不良和炎症是导致CKD发展的关键因素.
- 晚期肺癌炎症指数 (ALI) 与CKD之间的关联尚未得到充分证实.
研究的目的:
- 在美国成年人群中调查ALI和CKD之间的关系.
- 探索ALI作为CKD风险生物标志物的潜力.
主要方法:
- 对NHANES数据 (2003-2018) 的横截面分析.
- 权衡的多变量逻辑回归来评估ALI-CKD关联.
- 对非线性关系的平滑曲线拟合和值效应分析.
主要成果:
- 在ALI和CKD之间发现了显著的负相关性 (OR=0.93;p<0.0001).
- 随着ALI四分位数的增加,CKD风险下降,显示出L形负相关性.
- 在55.09.09的拐点观察到ALI对CKD风险的和效应.
结论:
- 晚期肺癌炎症指数 (ALI) 与美国成年人的慢性病 (CKD) 有显著的相关性.
- 研究结果表明,ALI可能作为CKD的潜在指标.
- 需要进一步的大规模前性研究来证实这些结果.
相关概念视频
Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Acute Kidney Injury I: Introduction
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...


