作为骨肌肉质量的标志物在腹腔透析患者中修改的肌素指数
Jack Kit-Chung Ng1, Winston Wing-Shing Fung1, Gordon Chun-Kau Chan1
1Carol & Richard Yu Peritoneal Dialysis Research Centre, Departments of Medicine & Therapeutics, Prince of Wales Hospital.
Clinical kidney journal
|October 21, 2024
概括
修改后的肌素指数 (MCrI) 是围透析 (PD) 患者骨肌肉质量的可靠标记. 该指数还可以预测PD患者在12个月内死亡的风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 老年病的医生 老年病的医生
- 生物化学 生物化学
背景情况:
- 麻症在腹腔透析 (PD) 患者中很普遍,影响他们的健康结果.
- 经过修改的肌素指数 (MCrI),用Canaud的公式和Kt/V计算,是血液透析患者肌肉质量的验证标记.
- 在PD患者中MCrI的实用性和计算尚未先前确定.
研究的目的:
- 评估MCrI作为PD患者骨肌肉质量的标记物的有效性.
- 评估MCrI与其他身体组成参数的相关性.
- 确定MCrI是否可以作为PD患者死亡率的预后指标.
主要方法:
- 研究了一组由138名从PD过渡到血液透析的患者组成的探索队列.
- 在PD期间使用Canaud公式计算MCrI,每周的Kt/V总和与血液透析后的MCrI转换相比较.
- 使用生物阻抗光谱和肌素动力学方法评估肌肉质量;分析了相关性.
- 这些发现在605名PD患者的单独队列中得到了验证.
主要成果:
- 在PD期间计算的MCrI显示,与血液透析相比,平均偏差为0.758 mg/kg/day.
- 显著相关的PD MCrI与肌肉质量通过肌动力学 (r=0.684) 和生物阻抗光谱学 (r=0.641) 测量.
- 在发生的PD患者中,MCrI四分位数与12个月内全因死亡的风险更高有关 (格雷测试,P=0.013).
结论:
- 使用Canaud公式和每周的Kt/V总值计算的MCrI是PD患者骨肌肉质量的简单可靠指标.
- MCrI可以作为PD患者群体中死亡风险的有价值的短期预后工具.
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