相关实验视频

Updated: Jun 10, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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图像化膜局部化和CB2R池的功能状态使用匹配的激动体和逆激动体探针对

M Wąsińska-Kałwa1, A Omran1, L Mach1

  • 1Leibniz-Forschungsinstitut für Molekulare Pharmakologie FMP Campus Berlin-Buch 13125 Berlin Germany nazare@fmp-berlin.de.

Chemical science
|October 21, 2024
PubMed
概括

研究人员开发了新的光探测器,以可视化大麻素受体2 (CB2R) 的活性和非活性状态. 这些选择性化学工具增强了对药物开发中的内分泌大麻素系统的理解.

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相关概念视频

The Two-State Receptor Model01:29

The Two-State Receptor Model

The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to induce or inhibit a biological response. When no natural ligands are present, a receptor exists in an equilibrium of inactive (Ri) and active (Ra) conformations. The inactive form does not produce a response, while the active form generates a basal effect known as constitutive activity.
The binding affinity of a drug determines its interaction with...
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