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在水中进行联合训练对海马神经元的作用健康老鼠的可塑性和记忆功能

Roya Askari¹, Mohadeseh NasrAbadi¹, Amir Hossein Haghighi¹

¹Department of Exercise Physiology, Faculty of Sport Science, Hakim Sabzevari University, Sabzevar, Iran.

AIMS neuroscience

|October 21, 2024

概括

基于水的训练可以促进老老鼠的神经生长因子 (NGF) 和CREB基因表达. 然而,这种联合练习并没有显著改善他们的工作记忆性能.

科学领域:

神经科学是一个神经科学.
运动生理学运动生理学
分子生物学分子生物学

背景情况:

循环AMP反应元素结合蛋白 (CREB) 和神经生长因子 (NGF) 对突触可塑性和大脑健康至关重要.
衰老与认知能力下降和神经可塑性降低有关.
了解可以减轻与年龄相关的认知衰退的干预措施是必不可少的.

研究的目的:

为了研究一个为期10周的水基联合训练计划对海马神经元可塑性和老老鼠记忆功能的影响.
评估这项培训对海马体CREB和NGF基因表达的影响.
用Y迷宫测试来评估工作记忆的性能.

主要方法:

16岁的雄性Wistar大鼠 (24个月大) 被分为组合训练 (n=8) 和对照 (n=8) 组.
训练组接受了为期10周的水力运动,每周4次.
河马NGF和CREB基因表达通过实时PCR测量,使用Y-迷宫测试评估工作记忆.

主要成果:

与对照组相比,水基训练在老老鼠的海马中显著增加了NGF和CREB基因表达 (P <0.05).
在训练组和对照组之间没有观察到Y迷宫表现的显著差异 (P > 0.05).

结论:

基于水的联合训练对与老老鼠神经可塑性相关的分子通路 (NGF,CREB) 有积极的影响.
需要进一步的研究来阐明这种训练对记忆巩固和衰老中的认知表现的功能影响.
这项研究强调了水上运动对大脑健康标志物的潜在益处,尽管没有立即可观察到的认知改善.

关键词:

克里布 (Creb) 是一个有趣的词汇.国家自然资源基金 (NGF)衰老的衰老衰老的衰老基于水的综合训练.记忆记忆记忆记忆记忆

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