同时存在的环境细颗粒物加剧了电子烟对人类呼吸道细胞的毒性
Guanghe Wang1, Wenjing Liu2, Yujie Cao1
1Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Inhalation toxicology
|October 21, 2024
概括
暴露于细颗粒物 (PM2.5) 和电子烟气溶的组合显著加重呼吸道细胞损伤. 薄荷风味的电子烟显示出更高的毒性,而PM2.5加剧了电子烟的影响,增加了氧化应激和炎症.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
背景情况:
- 同时暴露于环境细颗粒物 (PM2.5) 和电子烟 (电子烟) 气溶是常见的.
- 对呼吸系统的综合健康影响尚不清楚.
研究的目的:
- 研究PM2.5和电子烟气溶对人类呼吸系统细胞的副作用.
- 探索这些综合效应背后的潜在生物机制.
主要方法:
- A549/THP-1共同培养和BEAS-2B细胞暴露于电子液体,电子烟气溶提取物 (ECE),PM2.5或PM2.5 + ECE.
- 评估了细胞活力,活性氧物种 (ROS) 水平和炎症标记基因表达.
- 分析了NF-κB p65和NLRP3的蛋白质表达.
主要成果:
- 薄荷风味的电子液体的细胞毒性比烟草风味更高.
- 与单独使用ECE相比,PM2.5 + ECE暴露显著增加了ROS的产生和炎症.
- 同时暴露单独提高了NF-κB p65和NLRP3蛋白质表达.
- 电子烟风味对ROS和炎症的影响因细胞模型而异.
结论:
- PM2.5加剧了电子烟气溶对呼吸道细胞的不良影响.
- 电子烟的风味会影响细胞毒性,氧化应激和炎症,但影响取决于上下文.
- 联合暴露会激活关键的炎症通路 (NF-κB,NLRP3).
更多相关视频
09:30A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
Published on: January 18, 2018
8.3K
10:44Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
11.5K
相关概念视频
Stimulants
162
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
162
Types of Toxins
1.6K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.6K
