亚托瓦斯塔丁装载的糖体贴作为一种有效的透皮药物输送:优化和评估
Pravin Patil1, Mrunal Rahangdale1, Krutika Sawant1
1Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, 390001, Gujarat, India.
Therapeutic delivery
|October 21, 2024
概括
这项研究开发了阿托瓦斯塔丁 (ATO) 装载的糖体,用于通过皮肤输送,与口服相比,显示皮肤透性和持续释放性得到改善. 葡萄糖体为有效的药物输送提供了一个有希望的替代方案.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
背景情况:
- 口服阿托瓦斯塔丁 (ATO) 存在一些挑战.
- 葡萄糖体被探索为先进的囊泡系统,用于增强药物输送.
研究的目的:
- 为了制定和优化阿托瓦斯塔丁载荷糖体 (ATOG).
- 评估ATOG纳入皮肤贴片以改善药物输送.
主要方法:
- 用于ATOG配方的薄膜水化方法.
- 为优化提供最终的选设计.
- 将其纳入皮肤贴片中,并评估糖醇度的影响.
主要成果:
- 优化的ATOG表现出有利的特征 (大小,PDI,泽塔潜力,捕获效率,负载能力).
- 在体外研究表明,与纯的ATO相比,ATOG的持续释放,增强的皮肤透性和改善的细胞活力.
- ATOG贴片显示皮肤透性优于纯粹的ATO和脂质体贴片.
结论:
- 带有阿托瓦斯塔丁的葡萄糖体 (ATOG) 是有效的囊泡系统,可以通过皮肤传递.
- 葡萄糖体代表了一种有希望的方法来克服口服阿托瓦斯塔丁的局限性.
相关概念视频
Drug Delivery: Miscellaneous Routes
329
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329
Drug Delivery: Overview
278
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
278
Drug Delivery: Parenteral Route
434
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
434
Drug Delivery: Enteral Route
384
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
384
Routes of Drug Administration: Enteral
3.3K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
3.3K
Factors Influencing Drug Absorption: Pharmaceutical Parameters
121
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
121


