对于马感染性子宫内膜炎的非传统疗法的体外抗菌活性
Mariana P Mazzuchini1,2, Fernando Paixão Lisboa2, Jessica I de Castro3
1Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Champaign, Illinois, USA.
Equine veterinary journal
|October 21, 2024
概括
过氧化和富有血小板的血显示出作为马体内膜炎的替代治疗方法的希望,可能减少抗生素的使用. 需要进一步的体内研究来确认安全性和有效性.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 生殖生物学 生殖生物学
背景情况:
- 马类子宫内膜炎是马匹不育的主要原因.
- 过去对子宫内膜炎的抗生素使用缺乏理由,需要替代疗法.
- 合理使用抗生素需要探索新的治疗方案.
研究的目的:
- 评估非传统疗法的体外抗菌活性,以对抗马类子宫内膜炎的常见原因.
- 评估这些疗法在抑制微生物生长方面的疗效.
主要方法:
- 在体外实验中使用微稀释技术进行实验.
- 对关键病原体 (大肠杆菌,P. aeruginosa,K. pneumoniae,S. aureus,Candida sp.等) 的最小抑制度 (MIC) 和抑制率 (PI) 的确定. ) 的情况.
- 在MIC 100%和PI评估中使用了resazurin染料技术和光谱测量.
主要成果:
- 所有测试的疗法在所有微生物中都显示出比积极对照的抑制率 (PI) 更高的百分比.
- 只有过氧化和高血小板/低血小板血显示出对测试微生物的完全抑制 (MIC 100%).
- 观察到显著的抗微生物活性 (p < 0.05).
结论:
- 过氧化和富血小板/贫穷血显示出作为马类子宫内膜炎的替代治疗方法的潜力.
- 这些疗法可以支持减少传统抗生素的使用.
- 需要进一步的体内研究来确定安全性和临床疗效.
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