一种快速评估方法,用于质量一致性评估和Xiaohuoluo药丸的频谱效应关系研究,基于组合的光谱和染色学技术开发
Fangfang Cheng1,2, Yiting Gao2, Beibei Ren3
1Department of Clinical Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. wlj@hebmu.edu.cn.
Analytical methods : advancing methods and applications
|October 21, 2024
概括
这项研究开发了一种全面的质量控制方法Xiaohuoluo Pills (XHLP) 使用不同的指纹技术. 这种先进的方法确保了XHLP的质量,并为评估其他传统中医药提供了一个模型.
科学领域:
- 药理学是指药理学,即药理学是指药理学.
- 分析化学 分析化学
- 传统中国医学 (TCM) 质量控制 质量控制
背景情况:
- 确保传统中医药 (TCM) 的有效性和质量对于其进步至关重要.
- 一个科学合理的质量评估系统对于高质量的中医药生产至关重要.
研究的目的:
- 开发一个实用和全面的Xiaohuoluo Pills (XHLP) 质量控制方法.
- 采用多种指纹技术,以进行可靠的质量评估.
- 为了确定光谱形状和XHLP的疗效之间的相关性.
主要方法:
- 对于21个XHLP样本,已经确立了里叶变换红外光谱指纹 (FT-IRFP),紫外光谱指纹 (UVFP) 和聚变指纹 (FWFFP).
- 使用综合量化比指纹方法 (CQRFM) 进行指纹形状评估.
- 采用外部标准方法 (ESM) 来量化指标成分并测量抗氧化活性.
- 开发了一种使用直角投射到潜结构 (OPLS) 的光谱效率关系模型.
主要成果:
- 所有21批XHLP样品都符合基于CQRFM评估的质量要求.
- 使用ESM对三个指标组件的量化提高了质量控制系统.
- 建立了一个准确的光谱疗效关系图,将光谱数据与抗氧化活性相关联.
结论:
- 该研究成功开发了一种使用光谱和染色学技术的XHLP综合质量评估方法.
- 综合方法提供了对XHLP质量的定性和定量见解.
- 已经确立的光谱形状和抗氧化剂功效之间的相关性为XHLP和其他TCM的质量控制提供了有价值的模型.
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