皮克林乳液用于对刺激有反应的通过皮肤递送药物:质和微观结构对性能的影响
Simona Migliozzi1, Yiting He1,2, Maryam Parhizkar3
1Department of Chemical Engineering, University College London, London, UK. s.migliozzi@ucl.ac.uk.
Soft matter
|October 21, 2024
概括
具有量身定制的微凝大小的刺激响应皮克林乳液 (PE) 可提供受控的透皮药物递送. 微观结构,而不是散装特性,决定了药物释放,这种释放受到温度响应的微凝特性的影响.
科学领域:
- 材料科学 材料科学 材料科学
- 合体和表面化学
- 生物医学工程 生物医学工程
背景情况:
- 皮克林乳液 (PE) 是通过皮肤递送药物的有希望的.
- 响应刺激的微凝提供可调节的特性,可控制释放.
- 了解微凝尺寸和相互作用是优化PE性能的关键.
研究的目的:
- 为了研究刺激反应性皮克林乳液,用于通过皮肤递送药物.
- 探索微凝尺寸和相互作用对乳液修复学和药物释放的影响.
- 阐明微结构在控制药物释放动态中的作用.
主要方法:
- 合成不同尺寸的对温度有反应的聚烯酸 (N-异烯酸胺) 微凝 (pNIPAM-co-BVI).
- 使用合成微凝稳定Jojoba油在水中的缩乳液.
- 乳液的风湿学特征和通过皮肤递送药物的研究.
- 模拟药物释放作为通过多孔介质的扩散控制的传输.
主要成果:
- 小微凝 (∼300 nm) 产生了带有轻微产量应力的柔软玻璃状系统.
- 大型微凝 (∼800 nm) 诱导滴滴聚类,增加弹性和产出复杂性.
- 药物释放受到微观结构的控制,而不是大量的风湿学.
- 释放动力学取决于温度,由于微凝的多孔性,在生理温度 (37°C) 上释放时间增加.
结论:
- 微观结构的设计对于优化刺激响应PE对于通过皮肤递送药物至关重要.
- 微凝尺寸和温度反应性行为显著影响乳液特性和药物释放.
- 这些发现为开发具有可调节释放配置文件的先进药物输送系统提供了洞察力.
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