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Updated: Jun 9, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Published on: September 20, 2018

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药理学诱导ERα SUMOylation破坏了它的染色体结合

Lizhen Wang1,2, Ting Han2,3

  • 1PTN Joint Graduate Program, School of Life Sciences, Peking University, Beijing 100871, China.

ACS chemical biology
|October 21, 2024
PubMed
概括

选择性雌激素受体 (ER) 抑制剂通过诱导ERαSUMOylation来破坏ERα功能,这是一个抑制DNA结合的过程. 这种机制适用于SERM和SERD,如fulvestrant和elacestrant.

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