对药物的感知敏感性,报告的副作用和个人特征之间的关联:RCT的二次分析
Alexandra Kern1, Anja Fischbach-Zieger1, Claudia Witt1,2,3
1Institute for Complementary and Integrative Medicine, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
PloS one
|October 21, 2024
概括
患者对药物的敏感性 (PSM) 与更多报告的副作用有关,特别是在慢性腰痛患者中. 解决PSM和焦虑症可能有助于减少副作用的发生率.
科学领域:
- 疼痛管理 疼痛管理
- 精神病体医学是一种精神病体医学.
- 临床研究 临床研究
背景情况:
- 患者对药物的感知敏感性 (PSM) 可以影响报告的治疗副作用,并导致诸如不服药等费用.
- 关于nocebo机制和副作用报告的研究不如其临床影响所暗示的那么发达.
- 这项研究调查了PSM和慢性腰部疼痛 (CLBP) 患者接受针治疗的副作用之间的联系.
研究的目的:
- 探索PSM与CLBP患者报告的副作用之间的关联.
- 检查潜在的调解变量,包括性别,医疗保健利用,心理因素和治疗期望.
- 在非药物治疗背景下重新检查PSM和副作用之间的关系.
主要方法:
- 一项随机对照试验对CLBP患者治疗结果预期的二次分析.
- 对于所有变量,使用了自我评估措施.
- 使用相关性和回归分析来探索PSM,副作用和个人特征之间的关联.
主要成果:
- 分析了152名CLBP患者 (65.8%为女性,平均年龄为39.5) 的样本.
- 在PSM和报告的副作用之间发现了积极的相关性 (r = 0.24; p < 0.01).
- PSM也与焦虑正相关 (r = 0.21; p < 0.05),但焦虑并没有调节或调节PSM和副作用的关系.
结论:
- 关于PSM的早期研究得到了证实,并在特定的疼痛群体和非药物干预中得到了扩展.
- 结果强调了在患者治疗中解决PSM和焦虑问题的重要性.
- 针对PSM和焦虑症可能会减轻报告的副作用的患病率.
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