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相关概念视频

In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...

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相关实验视频

Updated: Jul 16, 2026

A Testing Platform for Durability Studies of Polymers and Fiber-reinforced Polymer Composites under Concurrent Hygrothermo-mechanical Stimuli
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动态/静态浸泡实验的改进和有效性分析.

Leilei Zhang1, Huiming An1, Qing Guo1

  • 1Baili College of Petroleum Engineering, Lanzhou City University, Lanzhou, China.

PloS one
|October 21, 2024
PubMed
概括

一个新的双重用途的实验设置改善了破裂水库的静态浸泡性测试. 它还可以在没有驱动力的情况下进行动态浸泡研究,揭示石油回收的最佳断裂宽度.

科学领域:

  • 石油工程是石油工程中的一个.
  • 储水库工程 储水库工程
  • 地质科学 地质科学

背景情况:

  • 在低透性破裂水库中,液体的流失对于石油回收至关重要.
  • 现有的静态和动态沉浸实验方法有局限性,包括空气污染,长时间的测试,以及无法消除驱动力的能力.

研究的目的:

  • 设计一个双重目的的实验设置和方法,用于静态和动态息研究.
  • 克服传统实验技术的局限性.
  • 为了研究骨折宽度对动态内的影响.

主要方法:

  • 开发了一种新的双重目的实验设置和静态和动态浸泡的方法.
  • 建议使用断裂液流速计算和发动机转速转换方法来设置动态浸泡参数.
  • 该设备与传统的静态浸泡瓶和动态替换方法进行了验证.

主要成果:

  • 与静态浸泡瓶相比,新设备的静态浸泡回收率提高了1.55%.
  • 动态浸泡回收率比动态浸泡驱动方法低3-6%,但孤立的流速效应.
  • 在断裂水库中最优的沉浸发生在宽度在50-100微米之间的断裂中.

结论:

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  • 开发的双重用途装置提供了一个更准确,更有效的方法来研究破裂水库中的沉浸.
  • 这些发现提供了关于断裂宽度在动态浸泡过程中的关键作用的见解.
  • 这项研究有助于改善低透性断裂系统的水库开发策略.