青少年患有肥胖和尼格里坎斯角膜神经损失的青少年
Hoda Gad1, Hajar Dauleh2, Shiga Chirayath2
1Research Department, Weill Cornell Medicine-Qatar, Doha, Qatar.
PloS one
|October 21, 2024
概括
患有尼格里卡斯白症 (AN) 的肥胖青少年表现出脂肪量增加和神经纤维早期损伤,这表明亚临床神经病变. 这凸显了监测AN青少年的代谢健康的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 儿科 儿科 儿科
背景情况:
- 肥胖和代谢障碍与成人外围神经病变有关.
- 黑色神经病症 (AN) 是胰岛素抵抗和相关的神经病变的代谢风险因素的标志物.
研究的目的:
- 为了调查 AN 肥胖青少年的小神经纤维损伤.
主要方法:
- 使用了身体组成分析,振动感知值 (VPT),单丝敏度和角膜共聚焦显微镜 (CCM).
- CCM量化了角膜神经纤维密度 (CNFD),分支密度 (CNBD),长度 (CNFL) 和下螺旋长度 (IWL).
主要成果:
- 与没有AN的肥胖青少年相比,患有AN的青少年体重,脂肪百分比和脂肪肌比较高.
- 患有AN的青少年表现出明显较低的角膜神经纤维密度 (CNFD).
- 在肥胖的青少年与没有AN之间,或对照人群之间,没有发现VPT,单丝纤维敏感度或其他CCM措施的显著差异.
结论:
- 患有AN的肥胖青少年表现出脂肪量增加和小的神经纤维损失的证据.
- 这表明该人群中存在亚临床神经病变,与代谢异常有关.
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