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Celsr3推动了声学启动后脑电路的开发和连接

Joy H Meserve¹, Maria F Navarro¹, Elelbin A Ortiz¹

¹Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

|October 21, 2024

概括

平面细胞极性 (PCP) 蛋白Celsr3和Celsr2指导斑马鱼启动电路中的神经元发育. 对于Celsr3和Celsr2来说,它们的不同角色确保了电路的正确组装和功能.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
分子生物学分子生物学

背景情况:

发育中的大脑形成了功能性神经回路,用于行为.
斑马鱼的声学惊反应依赖于一个定义的后脑电路.
已知神经元引导的分子通路,但不同神经元群体的共享通路尚不清楚.

研究的目的:

调查斑马鱼惊电路中不同的神经元群体是否使用共享的分子路径进行发育.
确定PCP相关蛋白Celsr3,Celsr2和Fzd3a在电路组件中的作用.

主要方法:

利用斑马鱼模型研究毛特纳细胞和螺旋纤维神经元中的轴突引导.
研究了Celsr3和Celsr2对于毛特纳细胞存活和螺旋纤维输入对称性的必要性.
比较了Celsr蛋白在启动电路发育中的作用与面部枝状运动神经元迁移.

主要成果:

Celsr3,Celsr2和Fzd3a对于毛特纳细胞和螺旋纤维神经元的轴突引导至关重要.
毛特纳轴突的生长对于毛特纳细胞的生存至关重要.
对称的螺旋纤维输入对于定向逃脱反应至关重要.
启动电路开发需要Celsr3,而Celsr2是不可用的,但可以补偿.
对于面部分支运动神经元迁移,Celsr2是必需的,与Celsr3.3不同.

结论:

揭示了PCP单个组件在组装声学惊后脑电路中的关键和独特作用.
在不同的神经发育过程中,对Celsr2和Celsr3的不同需求.

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