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Updated: Jul 22, 2026

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

Published on: November 28, 2014

由CD8细胞衍生的B粒酶可能是Takayasu动脉炎患者冠状动脉干扰和MACE的预测因子

Taotao Li¹, Na Gao¹, Juan Du¹

¹Department of Rheumatology and Immunology, Capital Medical University Affiliated Anzhen Hospital, Beijing, China.

Clinical and experimental immunology

|October 21, 2024

概括

产生CD8细胞的Granzyme B (GzmB) 在Takayasu动脉炎 (TAK) 冠状动脉干扰 (CAI) 患者中升高. 这一发现表明GzmB+ CD8细胞可以预测TAK中的CAI和心血管事件,提供潜在的治疗点.

科学领域:

免疫学免疫学免疫学
心脏病学心脏病学
类风湿病学类风湿病学

背景情况:

冠状动脉干扰 (CAI) 是高雅苏动脉炎 (TAK) 的一个重要并发症.
参与免疫反应和心血管疾病的蛋白酶Granzyme B (GzmB) 在CAI的TAK中起着不清楚的作用.

研究的目的:

调查Granzyme B (GzmB) 表达细胞子集在塔卡亚苏动脉炎 (TAK) 患者中的作用,特别是在冠状动脉干扰 (CAI) 方面.

主要方法:

流细胞计用于分析来自105名TAK患者和58名健康对照者的血液样本中的GzmB+细胞子集.
进行了统计分析,以比较细胞比例,并确定CAI和主要不良心血管事件 (MACE) 的风险因素.

主要成果:

与对照组相比,TAK患者的GzmB+淋巴细胞比例发生变化,CD3+CD8+GzmB+和CD3+CD4+GzmB+细胞增加,CD3-CD56+GzmB+细胞减少.
在TAK患者中观察到CD3+CD4+GzmB+,CD3+CD8+GzmB+和CD3-CD56+GzmB+细胞的比例较高,CAI患者与没有CAI患者相比.
增加的CD3+CD8+GzmB+细胞/淋巴细胞独立预测TAK患者的CAI (OR=4.990,P=0.002) 并与更高的MACE率相关.

结论:

由CD8细胞衍生的Granzyme B (GzmB) 可能成为Takayasu动脉炎 (TAK) 中冠状动脉干扰 (CAI) 和主要不良心血管事件 (MACE) 的有价值预测因素.
向CD3+CD8+GzmB+淋巴细胞或使用GzmB抑制剂是治疗TAK中CAI的潜在治疗策略.

关键词:

在 CD8+ 细胞中.这是一个GzmBB.塔卡亚苏的动脉炎是他的动脉炎冠状动脉的参与

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