METHA-NeP:甲对神经病痛的有效性和安全性:一项受控随机试验
Jorge Alberto Martins Pentiado Júnior1, Marcell Maduro Barbosa1, Gabriel Taricani Kubota1
1Pain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.
Pain
|October 21, 2024
概括
甲有效地减少了慢性神经病痛 (NP) 和改善睡眠,当用作补充治疗. 这项研究发现,在NP患者的疼痛缓解和整体改善方面,美沙优于安慰剂.
科学领域:
- 疼痛管理 疼痛管理
- 神经学 神经学
- 临床药理学 临床药理学
背景情况:
- 慢性神经病痛 (NP) 显著影响生活质量.
- 目前对NP的治疗方法通常具有有限的疗效或显著的副作用.
- 优化NP的附加疗法仍然是一个临床挑战.
研究的目的:
- 评估甲作为慢性神经病痛的补充疗法的疗效.
- 评估甲对疼痛强度,NP症状,睡眠,生活质量和情绪的影响.
- 确定这种患者群体中甲的安全性.
主要方法:
- 随机,双盲,安慰剂控制的临床试验.
- 八十六名慢性NP患者被随机分配给接受甲或安慰剂8周.
- 主要结局:通过视觉模拟尺度实现至少30%的疼痛缓解的参与者比例.
主要成果:
- 与安慰剂 (33%) 相比,甲组中显著更多的患者 (68%) 实现了30%的疼痛缓解.
- 甲降低了NP的疼痛强度,燃烧,压力和发维度 (P < 0.001).
- 使用甲,睡眠质量的改善 (P < 0.001) 和整体改善印象 (P = 0.002) 被观察到.
结论:
- 甲作为一种附加疗法,为慢性神经病痛提供了优越的止痛药.
- 甲改善睡眠和患者报告的NP变化的总体印象.
- 甲是NP的可行的治疗选择,可管理的不良事件和没有发现严重的安全问题.
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