社会黄蜂对极高度乙醇的耐受性和高效代谢
Sofia Bouchebti1, Yael Gershon1, Alexander Gordin2
1School of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
概括
东方大黄蜂可以容忍高度的乙醇,有效地代谢它而无害. 这种非凡的耐受性可能源于多个酒精脱酶基因拷贝,支持与乙醇生产生物的相互起源.
科学领域:
- 昆虫生理学和生物化学
- 动物行为 动物行为
- 进化生物学是进化的生物学.
背景情况:
- 乙醇是一种发酵副产品,存在于天然饮食中,但对于大多数动物来说,毒性超过4%.
- 东方大黄蜂 (Vespa orientalis) 自然消耗乙醇,这表明适应.
- 了解昆虫中的乙醇代谢对于生态和进化见解至关重要.
研究的目的:
- 为了研究东方黄蜂的乙醇代谢.
- 评估慢性高度乙醇消费对大黄蜂生存和行为的影响.
- 探索黄蜂中乙醇耐受性背后的潜在遗传机制.
主要方法:
- 长期暴露于不同度的乙醇 (高达80%).
- 行为测试测量死亡率,构建和痛苦的行为.
- 使用13C1标记的乙醇来追踪新陈代谢速率的代谢分析.
- 基因组比较分析侧重于酒精脱酶 (NADP+) 基因.
主要成果:
- 黄蜂甚至在80%的乙醇中也没有增加死亡率或行为变化.
- 黄蜂中乙醇代谢的效率明显高于蜜蜂.
- 韦斯帕属拥有酒精脱酶 (NADP+) 基因的多个副本.
结论:
- 东方大黄蜂对乙醇表现出异常的耐受性和代谢能力.
- 多个酒精脱酶基因拷贝可能有助于这种高乙醇耐受性.
- 这种适应可能是通过与乙醇生产生物的相互关系而演变的.
相关概念视频
Production of Alcohol
Continuous fermentation is a key strategy in industrial ethanol production, particularly when efficiency, scalability, and high yields are essential. This approach allows for uninterrupted operation and optimized resource utilization. The primary feedstock, corn starch, undergoes enzymatic hydrolysis facilitated by α-amylase and glucoamylase. These enzymes break down the starch into fermentable sugars such as glucose, which are readily assimilated by fermentative microorganisms.Fermentation...
Microbes in Beverage Production
Alcoholic beverages such as wine, beer, and spirits are the products of microbial fermentation processes that transform simple sugars into ethanol and a wide array of complex flavor compounds. These transformations rely on the metabolic activities of specific yeasts and bacteria, which are selected and controlled to yield the desired beverage characteristics.Wine Fermentation and MaturationWine production begins with the crushing of grapes to release juice and pulp, forming a must that is...
Bioreactor Controls-III
Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...


