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Updated: Jun 9, 2025

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毒性适应性列表设计:在瘤学中进行第一阶段药物组合试验的实用设计

Massimiliano Russo1, Francesco Mariani2, James M Cleary3,4

  • 1Department of Statistics, The Ohio State University, Columbus, OH.

JCO precision oncology
|October 21, 2024
PubMed
概括

我们为瘤学试验开发了一种新的毒性适应性列表设计 (TALE). TALE安全地确定药物组合的最大耐受剂量 (MTD),平衡患者安全和治疗疗效.

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