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Updated: Jun 9, 2025

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在胸腺中发现NEMO

Juan Moises Ocampo-Godinez1, Alexandra Y Kreins1,2

  • 1Infection Immunity and Inflammation Research and Teaching Department, University College London Institute of Child Health, London, UK.

The Journal of experimental medicine
|October 21, 2024
PubMed
概括

患有色素失禁和NEMO变异的患者对I型干扰素产生自身抗体,导致严重的病毒感染. 这表明NF-κB信号传递和免疫耐受性之间存在联系,尽管机制尚不清楚.

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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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