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通过使用生理学基础的药理动力学建模,了解洛斯波林对食物负面影响的机制

Ayahisa Watanabe1, Takanori Akazawa1, Motohiro Fujiu1

  • 1Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Japan.

Drug metabolism and pharmacokinetics
|October 21, 2024
PubMed
概括

由于在胃肠道吸附,食物会降低沃克洛斯波林的生物可用性. 基于生理学上的药理动力学 (PBPK) 建模表明,这种吸附是这种狼性炎药物观察到的负面食物效应的主要原因.

关键词:
吸附到食物中的吸附.这是一种循环.人类iPS衍生的肠上皮细胞.膜的透性 膜的透性食物的负面影响 食物的负面影响口服吸收 口服吸收在PBPK建模中使用PBPK模型.在Voclosporin中使用.

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