在基于大脑的视力障碍中,整合和隔离网络的重组
Ibai Diez1, Carla Troyas2, Corinna M Bauer3
1Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; Computational Neuroimaging Lab, Biobizkaia Health Research Institute, Barakaldo, Spain; IKERBASQUE Basque Foundation for Science, Bilbao, Spain.
NeuroImage. Clinical
|October 21, 2024
概括
大脑视力障碍 (CVI) 的儿童表现出大脑连接的改变. 他们的视觉网络重新组织,与感官区域集成,减少与其他大脑网络的联系,影响视觉功能.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 脑部成像 脑部成像
背景情况:
- 大脑连接与经验重组,但由于早期神经损伤与视力障碍相关的变化尚不清楚.
- 大脑视觉障碍 (CVI) 源于视觉处理通路的损伤,影响大脑组织.
研究的目的:
- 研究CVI患者与神经类型对照者的大脑连接差异.
- 使用多式成像和连接学方法分析结构和功能连接.
主要方法:
- 采用基于声素的形态测量 (VBM) 进行结构分析和静止状态功能连接 (rsfc) 进行功能分析.
- 进行了连接学分析,以评估加权程度和链接级连接.
主要成果:
- 患有CVI的个体在初级视觉皮层和内硫 (IPS) 中减少了灰质.
- CVI大脑显示了重新组织的连接性:与体感/注意网络的视觉整合增加,与边缘/默认模式网络的连接性下降.
- 链接级功能变化与临床视觉功能和发育结果相关联.
结论:
- 早期脑损伤相关的视力障碍明显地重组了大脑的功能网络架构.
- 研究结果提供了关于CVI神经基础及其对大脑组织和功能的影响的见解.
更多相关视频
相关概念视频
Visual System
552
Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
Once through the pupil, the light passes through the lens, a...
552
Vision
53.0K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
53.0K
Motor and Sensory Areas of the Cortex
3.0K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor...
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor...
3.0K
Visual Agnosia
176
Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
176
Neuroplasticity
303
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
303
Prosopagnosia
142
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
142


