晚期舌头唾液癌的治疗策略:一个多中心REFCOR研究
Valentine Poissonnet1, Emilien Chabrillac1, Emmanuelle Uro-Coste2
1Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Larrey Hospital, Toulouse, France.
Oral oncology
|October 21, 2024
概括
晚期唾液舌癌的彻底手术改善了局部控制,并可能增强吞功能. 然而,远程转移仍然是一个重大问题,需要进一步研究最佳治疗策略.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 罕见的癌症 罕见的癌症
背景情况:
- 舌头的唾液癌存在重大治疗挑战,原因是肢解的根基切除.
- 晚期需要仔细考虑瘤和功能结果.
研究的目的:
- 评估治疗舌头高级唾液癌的瘤和功能结果.
- 分析手术对生存和功能结果的影响.
主要方法:
- 一个回顾性多中心研究,包括舌头患者的T3-T4唾液癌 (2009-2018).
- 从法国罕见头癌国家网络 (REFCOR) 收集的数据.
- 对瘤结局 (无复发生存,远程转移) 和功能结局 (口服饮食,胃口) 的分析.
主要成果:
- 手术与改善的无复发生存率和本地/区域无复发生存率有关.
- 在手术和非手术组之间没有远程转移无存活率的统计差异.
- 在外科手术组的随访时,正常口服饮食的比例更高.
结论:
- 彻底手术主要改善了这些瘤的局部/区域控制,可能会增强长期的吞功能.
- 隐藏的远程转移在初始呈现时很常见.
- 需要进一步的研究来确定术后放射治疗和非手术治疗的作用.
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