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HLA-DR4Pred2:用于预测HLA-DRB1*04:01结合剂的改进方法

Sumeet Patiyal1, Anjali Dhall1, Nishant Kumar1

  • 1Department of Computational Biology, Indraprastha Institute of Information Technology, Okhla Phase 3, New Delhi 110020, India.

Methods (San Diego, Calif.)
|October 21, 2024
PubMed
概括

使用大型数据集和机器学习,HLA-DR4Pred2可以准确预测HLA-DRB1*04:01结合剂. 这个工具有助于开发免疫疗法和疫苗,用于COVID-19等相关疾病.

关键词:
抗原结合剂 抗原结合剂爆炸搜索搜索爆炸搜索在HLA-DRB1*04:01中.免疫治疗是一种免疫疗法.机器学习 机器学习预测方法 预测方法

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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