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儿童和青少年的尿酸参考值应按青春期阶段分层分类
Shurong Huang1, Qifa Hu2, Zhuoguang Li3
1Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China; School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|October 21, 2024
概括
确定儿童高尿血 (HUA) 的新参考值至关重要. 这些值因性别和青春期阶段而异,特别是在男孩中,并且与心血管疾病风险因素有关.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 公共卫生 公共卫生
- 评估心血管风险评估
背景情况:
- 在儿童和青少年中,高尿血 (HUA) 的患病率和参考值尚未得到充分确立.
- 了解影响血清尿酸 (SUA) 的因素对于儿科健康至关重要.
研究的目的:
- 确定儿童和青少年血清尿酸 (SUA) 的性别和青春期阶段特定的参考值.
- 调查SUA水平,体重指数 (BMI),青春期阶段和心血管疾病 (CVD) 风险因素之间的关系.
主要方法:
- 对4807名学生的数据进行量子回归分析.
- 检查年龄,BMI,青春期阶段和SUA之间的关联.
- 接收器操作特征 (ROC) 分析以确定 SUA 参考值.
主要成果:
- 使用成人标准,HUA的患病率在男孩中为34.3%,在女孩中为29%.
- 随着更高的BMI,年龄和青春期阶段,SUA水平增加.
- 较高的SUA与心血管疾病风险因素的增加相关,青春期阶段对男孩的SUA和女孩的营养状况产生重大影响.
结论:
- 根据青春期阶段的分层HUA参考值,特别是对于男孩来说,是必不可少的.
- 根据性别和青春期的发展,建议的参考值有很大的差异.
- 长期随访可能会改进这些关键的儿科SUA参考值.
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