橄克隆带的存在预测了在孤立的骨髓炎中转化为多发性硬化症的情况
Tobias Monschein1,2, Markus Ponleitner1,2, Gabriel Bsteh1,2
1Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Scientific reports
|October 21, 2024
概括
鉴定可能患上多发性硬化症 (MS) 的急性横侧髓炎 (ATM) 患者至关重要. 大脑脊髓液特定的基基隆带 (CSF-OCB) 是单独的ATM病例中MS转化的唯一预测因素.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 急性横侧髓炎 (ATM) 是一种脊髓炎症,原因多种多样.
- 从临床上来说,将孤立的ATM与早期多发性硬化症 (MS) 区分开来是非常重要的.
研究的目的:
- 确定初始隔离ATM患者转化为确定的MS的预测因素.
- 分析临床,实验室和成像数据,以预测MS转化预测因素.
主要方法:
- 对42名被诊断患有孤立ATM的患者 (1999-2019) 的回顾性分析.
- 纳入标准:孤立的ATM诊断和腰部穿刺.
- 审查的数据:临床,CSF分析,唤起的潜力,MRI.
主要成果:
- 在42名患者中,12名患者 (29%) 在中位数7.7年的随访期间转化为MS.
- 多发性硬化转换者较年轻,CSF/血清白蛋白和CSF总蛋白质较低.
- 83%的MS转换器与30%的非转换器 (p=0.002) 中存在CSF特异性橄克隆带 (OCB).
结论:
- 特定于CSF的OCB是MS转换到孤立的ATM的唯一显著预测因素.
- 及时的CSF分析和量身定制的后续对这些患者至关重要.
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